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Microcrystalline cellulose as filler in polycaprolactone matrices

Alemán-Domínguez, M; Ortega, Z; Benítez, A; Monzón, M; Wang, L; Tamaddon, M; Liu, C; (2020) Microcrystalline cellulose as filler in polycaprolactone matrices. In: Industry 4.0 – Shaping The Future of The Digital World Proceedings of the 2nd International Conference on Sustainable Smart Manufacturing (S2M 2019), 9–11 April 2019, Manchester, UK. CRC press: Manchester, UK. Green open access

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Abstract

Polycaprolactone is a biomaterial widely used for tissue engineering applications. However, its hydrophobicity hinders cell attachment and proliferation on its surface. In this study microcrystalline cellulose has been proposed as a functional filler for polycaprolactone matrices expected to improve these properties. Composite material samples containing 0, 2, 5, 10 and 20% w/w of microcrystalline cellulose have been manufactured by compression molding and evaluated in terms of their mechanical properties, swelling behavior, water contact angle values and sheep mesenchymal cells viability. The results confirm that the presence of the additive is able to increase the swelling ability of the material (the samples containing 20% w/w of additive are able to absorb an amount of water 6 times higher than the value for polycaprolactone ones), the Young’s modulus (from 224±14 MPa for polycaprolactone to 388±30 MPa for the composites containing 20% of microcrystalline cellulose) and the bioaffinity of polycaprolactone based composite materials.

Type: Proceedings paper
Title: Microcrystalline cellulose as filler in polycaprolactone matrices
Event: Industry 4.0–Shaping The Future of The Digital World
Location: Manchester, UK
Dates: 09 April 2019 - 11 April 2019
Open access status: An open access version is available from UCL Discovery
DOI: 10.1201/9780367823085-43
Publisher version: https://www.taylorfrancis.com/books/e/978036782308...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10115403
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