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Acute liver failure: updates in pathogenesis and management

Amin, AA; Agarwal, B; Jalan, R; (2019) Acute liver failure: updates in pathogenesis and management. Medicine , 47 (12) pp. 838-842. 10.1016/j.mpmed.2019.09.010. Green open access

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Abstract

Acute liver failure is a life-threatening illness precipitated by an acute liver injury in patients with no pre-existing liver disease. Acute viral hepatitis and drug-induced liver injury account for most cases, the clinical course characterized by the development of coagulopathy and hepatic encephalopathy, often progressing to multi-organ disease, which is associated with high fatality rates. The outcomes have improved significantly over time with improving standards of organ system support and access to liver transplantation for very sick individuals. The King's College criteria are the most commonly used tool for determination of prognosis and consideration for transplantation. Prompt diagnosis, immediate initiation of supportive care and aetiology-specific treatment, where applicable, as well as early discussions and transfer to a transplant centre, are the keys to successful outcome.

Type: Article
Title: Acute liver failure: updates in pathogenesis and management
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2019.09.010
Publisher version: https://doi.org/10.1016/j.mpmed.2019.09.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Acute liver failure, fulminant hepatitis, critical care, hepatic encephalopathy, multi-organ failure, intensive care, liver transplantation.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10115342
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