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Mitochondrial shaping proteins as novel treatment targets for cardiomyopathies

Kalkhoran, SB; Hernandez-Resendiz, S; Ong, S-G; Ramachandra, CJA; Hausenloy, DJ; (2020) Mitochondrial shaping proteins as novel treatment targets for cardiomyopathies. Conditioning Medicine , 3 (4) pp. 216-226. Green open access

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Abstract

Heart failure (HF) is one of the leading causes of death and disability worldwide. The prevalence of HF continues to rise, and its outcomes are worsened by risk factors such as age, diabetes, obesity, hypertension, and ischemic heart disease. Hence, there is an unmet need to identify novel treatment targets that can prevent the development and progression of HF in order to improve patient outcomes. In this regard, cardiac mitochondria play an essential role in generating the ATP required to maintain normal cardiac contractile function. Mitochondrial dysfunction is known to contribute to the pathogenesis of a number of cardiomyopathies including those secondary to diabetes, pressure-overload left ventricular hypertrophy (LVH), and doxorubicin cardiotoxicity. Mitochondria continually change their shape by undergoing fusion and fission, and an imbalance in mitochondrial fusion and fission have been shown to impact on mitochondrial function, and contribute to the pathogenesis of these cardiomyopathies. In this review article, we focus on the role of mitochondrial shaping proteins as contributors to the development of three cardiomyopathies, and highlight their therapeutic potential as novel treatment targets for preventing the onset and progression of HF.

Type: Article
Title: Mitochondrial shaping proteins as novel treatment targets for cardiomyopathies
Location: United States
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.conditionmed.org/Data/View/9539
Language: English
Additional information: Conditioning Medicine is an open-access journal, which means that all content is freely available without charge to users and institutions under the terms of the Creative Commons Attribution License. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author.
Keywords: Mitochondrial morphology, heart failure, diabetic cardiomyopathy, left ventricular hypertrophy, doxorubicin cardiotoxicity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10115278
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