Wingrove, JO;
O'Daly, O;
Forbes, B;
Swedrowska, M;
Amiel, SA;
Zelaya, FO;
(2021)
Intranasal insulin administration decreases cerebral blood flow in cortico‐limbic regions: A neuropharmacological imaging study in normal and overweight males.
Diabetes, Obesity and Metabolism
, 23
(1)
pp. 175-185.
10.1111/dom.14213.
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Abstract
Aim: To assess and compare the effects of 160 IU intranasal insulin (IN‐INS) administration on regional cerebral blood flow (rCBF) in healthy male individuals with normal weight and overweight phenotypes. / Methods: Thirty young male participants (mean age 25.9 years) were recruited and stratified into two cohorts based on body mass index: normal weight (18.5‐24.9 kg/m2) and overweight (25.0‐29.9 kg/m2). On separate mornings participants received 160 IU of IN‐INS using an intranasal protocol and intranasal placebo as part of a double‐blind crossover design. Thirty minutes following administration rCBF data were collected using a magnetic resonance imaging method called pseudocontinuous arterial spin labelling. Blood samples were collected to assess insulin sensitivity and changes over time in peripheral glucose, insulin and C‐peptide. / Results: Insulin sensitivity did not significantly differ between groups. Compared with placebo, IN‐INS administration reduced rCBF in parts of the hippocampus, insula, putamen, parahippocampal gyrus and fusiform gyrus in the overweight group. No effect was seen in the normal weight group. Insula rCBF was greater in the overweight group versus normal weight only under placebo conditions. Peripheral glucose and insulin levels were not affected by IN‐INS. C‐peptide levels in the normal weight group decreased significantly over time following IN‐INS administration but not placebo. / Conclusion: Insulin‐induced changes within key regions of the brain involved in gustation, memory and reward were observed in overweight healthy male individuals. Following placebo administration, differences in gustatory rCBF were observed between overweight and normal weight healthy individuals.
| Type: | Article |
|---|---|
| Title: | Intranasal insulin administration decreases cerebral blood flow in cortico‐limbic regions: A neuropharmacological imaging study in normal and overweight males |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/dom.14213 |
| Publisher version: | https://doi.org/10.1111/dom.14213 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | cerebral blood flow, hippocampus, intranasal insulin, normal weight, overweight |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10115258 |
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