Lopez-Gonzalez, D;
Wells, JC;
Cortina-Borja, M;
Fewtrell, M;
Partida-Gaytán, A;
Clark, P;
(2020)
Reference values for bone mineral density in healthy Mexican children and adolescents.
Bone
, Article 115734. 10.1016/j.bone.2020.115734.
(In press).
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Abstract
Introduction: Clinical assessment of bone health by Dual‐Energy X-ray Absorptiometry (DXA) in the paediatric population requires robust reference values. The International Society for Clinical Densitometry (ISCD) recommends that country/regional reference values ideally should be used to improve precision in bone health assessment. / Objective: The aim of this study was to provide reference values for relevant bone health variables for healthy Mexican children and adolescents aged 5 to 18 years. / Methods: This was a cross-sectional, stratified and population-based study, that measured a representative sample of healthy Mexican children and adolescents with DXA. We constructed age- and sex-smoothed reference values for areal bone mineral density (aBMD) of total body less head (TBLH), total body (TB), lumbar spine (LS), and bone mineral apparent density (BMAD) for LS, by means of Generalized Additive Models for Location, Scale and Shape (GAMLSS). / Results: Reference data including the 3th, 5th, 10th, 25th, 50th, 75th, 90th, 95th and 97th centiles, along with lambda (L), mu (M) and sigma (S) values, are given for each variable of interest for each sex at 0.25 years intervals. Reference values relative to height and Tanner-stage for both sexes are also provided. Finally, formulas to enable Z score estimation for clinical use are also presented. / Conclusions: The sex, age, height, Tanner-stage and ethnic-specific reference data provided in this study should enable more precise assessment of bone health in the Mexican paediatric population. The data presented may also allow for future evaluation of potential similarities and differences across different ethnic groups.
| Type: | Article |
|---|---|
| Title: | Reference values for bone mineral density in healthy Mexican children and adolescents |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bone.2020.115734 |
| Publisher version: | https://doi.org/10.1016/j.bone.2020.115734 |
| Language: | English |
| Additional information: | This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Bone mineral density, Children, Adolescents, Reference values, Dual Energy X-ray Absorptiometry, Mexican, Bone health, Bone mineral apparent density |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10115191 |
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