UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis

Patel, S; Malmberg, K-J; (2020) Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis. Cell Calcium , 92 , Article 102289. 10.1016/j.ceca.2020.102289. Green open access

[thumbnail of Patel_Patel and Malmberg 2020 revised.pdf]
Preview
 Text
Patel_Patel and Malmberg 2020 revised.pdf - Accepted Version
Download (370kB) | Preview

Abstract

The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca2+ mobilising messenger NAADP and the phosphoinositide PI(3,5)P2. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca2+ release and secretion in mast cells.

Type: Article
Title: Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceca.2020.102289
Publisher version: https://doi.org/10.1016/j.ceca.2020.102289
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Mast cells, NAADP, Secretion, TPC1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10114784
Downloads since deposit
84Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item