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Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior

Robinson, NTM; Descamps, LAL; Russell, LE; Buchholz, MO; Bicknell, BA; Antonov, GK; Lau, JYN; ... Häusser, M; + view all (2020) Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior. Cell 10.1016/j.cell.2020.09.061. (In press). Green open access

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Abstract

The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an ‘all-optical’ combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory.

Type: Article
Title: Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2020.09.061
Publisher version: https://doi.org/10.1016/j.cell.2020.09.061
Language: English
Additional information: Copyright © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: place cell, hippocampus, memory, spatial navigation, all-optical interrogation, two-photon optogenetics, two-photon calcium imaging, virtual reality, inhibition, behavior
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10114718
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