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Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa

Aswad, A; Aimola, G; Wight, D; Roychoudhury, P; Zimmermann, C; Hill, J; Lassner, D; ... Kaufer, BB; + view all (2020) Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa. Molecular Biology and Evolution 10.1093/molbev/msaa190. (In press). Green open access

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Abstract

Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result, ∼70 million people harbor the genome of one of these viruses in every cell of their body. Until now, it has been largely unknown if 1) these integrations are ancient, 2) if they still occur, and 3) whether circulating virus strains differ from integrated ones. Here, we used next-generation sequencing and mining of public human genome data sets to generate the largest and most diverse collection of circulating and integrated HHV-6 genomes studied to date. In genomes of geographically dispersed, only distantly related people, we identified clades of integrated viruses that originated from a single ancestral event, confirming this with fluorescent in situ hybridization to directly observe the integration locus. In contrast to HHV-6B, circulating and integrated HHV-6A sequences form distinct clades, arguing against ongoing integration of circulating HHV-6A or “reactivation” of integrated HHV-6A. Taken together, our study provides the first comprehensive picture of the evolution of HHV-6, and reveals that integration of heritable HHV-6 has occurred since the time of, if not before, human migrations out of Africa.

Type: Article
Title: Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/molbev/msaa190
Publisher version: https://doi.org/10.1093/molbev/msaa190
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: human herpesvirus 6, phylogenetics, genomics, paleovirology, telomere biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10114653
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