Steeples, LR;
Spry, P;
Lee, RWJ;
Carreno, E;
(2018)
Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy.
International Ophthalmology
, 38
(3)
pp. 1357-1362.
10.1007/s10792-017-0592-5.
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Abstract
Purpose To report the clinical outcomes of adalimumab therapy in cases of birdshot chorioretinitis (BCR) with cystoid macular edema (CME) refractory to conventional immunotherapy. Methods This is a retrospective case series of three BCR patients treated with adalimumab for refractory CME. The main outcome measure was central subfield thickness (CST) on optical coherence tomography. Any patients treated with local steroids and/or receiving systemic steroids higher than 40 mg prednisolone daily during adalimumab therapy were excluded. Results At baseline, all patients were receiving systemic corticosteroids and two second-line immunosuppressive agents. The mean duration of treatment with adalimumab was 31.2 months (range 17.2–52). The mean CST was 327 ± 112.7 μm (mean ± SD) at baseline and 256.2 ± 39.7 μm at 6 months and 235.5 ± 32.5 μm at 12 months. Adalimumab permitted cessation or reduction in the daily dose of oral prednisolone plus withdrawal of a second-line agent in all patients. Conclusions In these patients, adalimumab was effective in the treatment of refractory CME.
Type: | Article |
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Title: | Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1007/s10792-017-0592-5 |
Publisher version: | https://doi.org/10.1007/s10792-017-0592-5 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, Birdshot chorioretinopathy, Birdshot chorioretinitis, Adalimumab, Anti-tumor necrosis factor alpha (anti-TNF), Cystoid macular edema, TERM-FOLLOW-UP, NONINFECTIOUS UVEITIS, RETINOCHOROIDOPATHY, THERAPY |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10114554 |
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