Lam, KH;
Meijer, KA;
Loonstra, FC;
Coerver, EME;
Twose, J;
Redeman, E;
Moraal, B;
... Killestein, J; + view all
(2020)
Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis.
Multiple Sclerosis Journal
10.1177/1352458520968797.
(In press).
Preview |
Text
Barkhof_Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis_AOP.pdf - Published Version Download (591kB) | Preview |
Abstract
Background: Clinical measures in multiple sclerosis (MS) face limitations that may be overcome by utilising smartphone keyboard interactions acquired continuously and remotely during regular typing. Objective: The aim of this study was to determine the reliability and validity of keystroke dynamics to assess clinical aspects of MS. Methods: In total, 102 MS patients and 24 controls were included in this observational study. Keyboard interactions were obtained with the Neurokeys keyboard app. Eight timing-related keystroke features were assessed for reliability with intraclass correlation coefficients (ICCs); construct validity by analysing group differences (in fatigue, gadolinium-enhancing lesions on magnetic resonance imaging (MRI), and patients vs controls); and concurrent validity by correlating with disability measures. Results: Reliability was moderate in two (ICC = 0.601 and 0.742) and good to excellent in the remaining six features (ICC = 0.760–0.965). Patients had significantly higher keystroke latencies than controls. Latency between key presses correlated the highest with Expanded Disability Status Scale (r = 0.407) and latency between key releases with Nine-Hole Peg Test and Symbol Digit Modalities Test (ρ = 0.503 and r = −0.553, respectively), ps < 0.001. Conclusion: Keystroke dynamics were reliable, distinguished patients and controls, and were associated with clinical disability measures. Consequently, keystroke dynamics are a promising valid surrogate marker for clinical disability in MS.
| Type: | Article |
|---|---|
| Title: | Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1352458520968797 |
| Publisher version: | http://dx.doi.org/10.1177/1352458520968797 |
| Language: | English |
| Additional information: | © The Author(s), 2020. https://creativecommons.org/licenses/by-nc/4.0/ Article reuse guidelines: sagepub.com/journalspermissions |
| Keywords: | Multiple sclerosis, disability evaluation, upper extremity, cognition, smartphone, touch typing, ambulatory monitoring, ecological momentary assessment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114540 |
Archive Staff Only
 |
View Item |
