Schotten, C;
Howard, JL;
Jenkins, RL;
Codina, A;
Browne, DL;
(2018)
A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring.
Tetrahedron
, 74
(38)
pp. 5503-5509.
10.1016/j.tet.2018.05.070.
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Abstract
Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF2H after 105 min.
| Type: | Article |
|---|---|
| Title: | A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tet.2018.05.070 |
| Publisher version: | http://dx.doi.org/10.1016/j.tet.2018.05.070 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Continuous flow, Flow NMR, Inline monitoring, Exotherm control, Space time yield |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114374 |
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