Juergens, S;
Scalcon, V;
Estrada-Ortiz, N;
Folda, A;
Tonolo, F;
Jandl, C;
Browne, DL;
... Casini, A; + view all
(2017)
Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes.
Bioorganic & Medicinal Chemistry
, 25
(20)
pp. 5452-5460.
10.1016/j.bmc.2017.08.001.
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Abstract
A family of cyclometalated Au(III) complexes featuring a tridentate C^N^C scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(C^N^C)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules.
| Type: | Article |
|---|---|
| Title: | Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bmc.2017.08.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.bmc.2017.08.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Gold(III) complexes, Cyclometalation, Anticancer agents, Thioredoxin reductase, Thiols, TRANSITION-METAL-COMPLEXES, HETEROCYCLIC CARBENE COMPLEXES, ANTIPROLIFERATIVE PROPERTIES, THIOREDOXIN REDUCTASE, CYTOTOXIC PROPERTIES, ANTICANCER AGENTS, CHEMISTRY, GOLD, PURIFICATION, SYSTEM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114347 |
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