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Progress and perspective of microneedle system for anti-cancer drug delivery

Li, D; Hu, D; Xu, H; Patra, HK; Liu, X; Zhou, Z; Tang, J; ... Shen, Y; + view all (2021) Progress and perspective of microneedle system for anti-cancer drug delivery. Biomaterials , 264 , Article 120410. 10.1016/j.biomaterials.2020.120410. Green open access

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Abstract

Transdermal drug delivery exhibited encouraging prospects, especially through superficial drug administration routes. However, only a few limited lipophilic drug molecules could cross the skin barrier, those are with low molecular weight and rational Log P value. Microneedles (MNs) can overcome these limitations to deliver numerous drugs into the dermal layer by piercing the outermost skin layer of the body. In the case of superficial cancer treatments, topical drug administration faces severely low transfer efficiency, and systemic treatments are always associated with side effects and premature drug degradation. MN-based systems have achieved excellent technical capabilities and been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy. In this review, we will focus on the features, progress, and opportunities of MNs in the anticancer drug delivery system. Then, we will discuss the strategies and advantages in these works and summarize challenges, perspectives, and translational potential for future applications.

Type: Article
Title: Progress and perspective of microneedle system for anti-cancer drug delivery
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biomaterials.2020.120410
Publisher version: https://doi.org/10.1016/j.biomaterials.2020.120410
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cancer therapy, Gene therapy, Immunotherapy, Microneedle, Phototherapy, Transdermal drug delivery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10114246
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