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Restoring neuron connections

Salinas, PC; (2020) Restoring neuron connections. Science , 369 (6507) pp. 1052-1053. 10.1126/science.abd4762. Green open access

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Abstract

The structural and functional integrity of synapses is crucial for neuronal circuit function and for the ability of animals to respond and adapt to their environment. However, synapses become dysfunctional or are lost in developmental and neurodegenerative disorders, and after brain and spinal cord injury (SCI). Deficiency in synapse integrity contributes to cognitive impairment and motor disability. To restore damaged neuronal circuits after SCI, antibody therapy against molecules such as Nogo, which inhibits axon growth, are in clinical trials (1). For other conditions such as Alzheimer's disease (AD), blockade of the pathogenic molecule amyloid-β or its downstream effects are being tested as potential therapies (2). To develop effective approaches for restoring impaired synapses, careful consideration should be given to the diversity of synaptogenic factors. To overcome this, on page 1074 of this issue, Suzuki et al. (3) report a structurally guided synthetic peptide to restore synaptic integrity of damaged and impaired circuits in mice.

Type: Article
Title: Restoring neuron connections
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.abd4762
Publisher version: https://doi.org/10.1126/science.abd4762
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10114201
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