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Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping

Mezil, S; Caravaca-Aguirre, AM; Zhang, EZ; Moreau, P; Wang, I; Beard, PC; Bossy, E; (2020) Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping. Biomedical Optics Express , 11 (10) pp. 5717-5727. 10.1364/BOE.400686. Green open access

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Abstract

We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and raster-scanned over a sample at the distal tip of the fiber by use of a fast spatial light modulator. An ultra-sensitive fiber-optic ultrasound sensor for photoacoustic detection placed next to the fiber is combined with a photodetector to obtain both fluorescence and photoacoustic images with a distal imaging tip no larger than 250 µm. The high signal-to-noise ratio provided by wavefront shaping based focusing and the ultra-sensitive ultrasound sensor enables imaging with a single laser shot per pixel, demonstrating fast two-dimensional hybrid in vitro imaging of red blood cells and fluorescent beads.

Type: Article
Title: Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/BOE.400686
Publisher version: https://doi.org/10.1364/BOE.400686
Language: English
Additional information: © 2020 Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10113696
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