Mezil, S;
Caravaca-Aguirre, AM;
Zhang, EZ;
Moreau, P;
Wang, I;
Beard, PC;
Bossy, E;
(2020)
Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping.
Biomedical Optics Express
, 11
(10)
pp. 5717-5727.
10.1364/BOE.400686.
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Abstract
We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and raster-scanned over a sample at the distal tip of the fiber by use of a fast spatial light modulator. An ultra-sensitive fiber-optic ultrasound sensor for photoacoustic detection placed next to the fiber is combined with a photodetector to obtain both fluorescence and photoacoustic images with a distal imaging tip no larger than 250 µm. The high signal-to-noise ratio provided by wavefront shaping based focusing and the ultra-sensitive ultrasound sensor enables imaging with a single laser shot per pixel, demonstrating fast two-dimensional hybrid in vitro imaging of red blood cells and fluorescent beads.
| Type: | Article |
|---|---|
| Title: | Single-shot hybrid photoacoustic-fluorescent microendoscopy through a multimode fiber with wavefront shaping |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/BOE.400686 |
| Publisher version: | https://doi.org/10.1364/BOE.400686 |
| Language: | English |
| Additional information: | © 2020 Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113696 |
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