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Survhe: Survival analysis for health economic evaluation and cost-effectiveness modeling

Baio, G; (2020) Survhe: Survival analysis for health economic evaluation and cost-effectiveness modeling. Journal of Statistical Software , 95 (14) 10.18637/jss.v095.i14. Green open access

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Abstract

Survival analysis features heavily as an important part of health economic evaluation, an increasingly important component of medical research. In this setting, it is important to estimate the mean time to the survival endpoint using limited information (typically from randomized trials) and thus it is useful to consider parametric survival models. In this paper, we review the features of the R package survHE, specifically designed to wrap several tools to perform survival analysis for economic evaluation. In particular, survHE embeds both a standard, frequentist analysis (through the R package flexsurv) and a Bayesian approach, based on Hamiltonian Monte Carlo (via the R package rstan) or integrated nested Laplace approximation (with the R package INLA). Using this composite approach, we obtain maximum flexibility and are able to pre-compile a wide range of parametric models, with a view of simplifying the modelers’ work and allowing them to move away from non-optimal work flows, including spreadsheets (e.g., Microsoft Excel).

Type: Article
Title: Survhe: Survival analysis for health economic evaluation and cost-effectiveness modeling
Open access status: An open access version is available from UCL Discovery
DOI: 10.18637/jss.v095.i14
Publisher version: http://dx.doi.org/10.18637/jss.v095.i14
Language: English
Additional information: This work is licensed under the licenses Paper: Creative Commons Attribution 3.0 Unported License
Keywords: Survival analysis, health economic evaluation, probabilistic sensitivity analysis, R.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10113418
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