O'Hara, J;
Way, B;
Borghi, A;
Knoops, PGM;
Chua, D;
Hayward, RD;
(2019)
The turricephaly index: A validated method for recording turricephaly and its natural history in Apert syndrome.
Journal of Cranio-Maxillofacial Surgery
, 47
(3)
pp. 414-419.
10.1016/j.jcms.2018.12.007.
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Abstract
Introduction: We present the CT scan-derived turricephaly index (TI) as a quotient of the maximal occipito-frontal length of the skull to the distance from the centre of the sella to the highest point on the vertex as a validated tool for assessing turricephaly and evaluating surgical techniques aimed at reducing it. Materials and methods: Measurements taken from CTs of non-operated children with Apert syndrome and age-matched controls were analysed using Centricity PACS system (from the lateral scout image) and the thick-sliced Osirix tool. CTs from non-operated children with Apert syndrome were used to investigate the natural history of their turricephaly both as a group and individually. Results: There was statistically significant agreement between measurements taken from the CT scout and Osirix for 42 control children (R2 = 0.97) and 42 children with Apert syndrome (R2 = 0.98) and between two separate observers. There was a statistically significant difference (p < 0.001) between CT scout-derived TI value between controls (1.73 ± 0.12, range 1.46–1.99) and Apert children (1.42 ± 0.15, range 1.13–1.73). Analysis of 113 CTs of 65 non-operated children with Apert syndrome showed a decrease in turricephaly with age (positive spearman correlation: r = 0.50, p < 0.001). Analysis of 37 CTs of those with multiple (>2) CT's showed a similar decrease in turricephaly in the individual child (p < 0.001). Conclusions: TI derived from the CT scout view provides a simple, objective and validated method for assessing turricephaly. We recommend it for monitoring and for the prospective evaluation of reconstructive techniques in children with complex/syndromic craniosynostosis.
| Type: | Article |
|---|---|
| Title: | The turricephaly index: A validated method for recording turricephaly and its natural history in Apert syndrome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jcms.2018.12.007 |
| Publisher version: | https://doi.org/10.1016/j.jcms.2018.12.007 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Turricephaly, Turricephaly index, Craniosynostosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113038 |
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