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The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis

Platé, M; Guillotin, D; Chambers, RC; (2020) The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis. European Respiratory Review , 29 (157) , Article 200269. 10.1183/16000617.0269-2020. Green open access

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Abstract

Idiopathic pulmonary fibrosis (IPF) is characterised by the progressive deposition of excessive extracellular matrix proteins within the lung parenchyma and represents the most rapidly progressive and fatal of all fibrotic conditions. Current anti-fibrotic drugs approved for the treatment of IPF fail to halt disease progression and have significant side-effect profiles. Therefore, there remains a pressing need to develop novel therapeutic strategies for IPF. Mammalian target of rapamycin (mTOR) forms the catalytic subunit of two complexes, mTORC1 and mTORC2. mTORC1 acts as critical cellular sensor which integrates intracellular and extracellular signals to reciprocally regulate a variety of anabolic and catabolic processes. The emerging evidence for a critical role for mTORC1 in influencing extracellular matrix production, metabolism, autophagy and senescence in the setting of IPF highlights this axis as a novel therapeutic target with the potential to impact multiple IPF pathomechanisms.

Type: Article
Title: The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1183/16000617.0269-2020
Publisher version: https://doi.org/10.1183/16000617.0269-2020
Language: English
Additional information: This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. See: https://creativecommons.org/licenses/by-nc/4.0/deed.en
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10112751
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