Li, N;
Mrsic-Flogel, TD;
(2020)
Cortico-cerebellar interactions during goal-directed behavior.
Current Opinion in Neurobiology
, 65
pp. 27-37.
10.1016/j.conb.2020.08.010.
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Abstract
Preparatory activity is observed across multiple interconnected brain regions before goal-directed movement. Preparatory activity reflects discrete activity states representing specific future actions. It is unclear how this activity is mediated by multi-regional interactions. Recent evidence suggests that the cerebellum, classically associated with fine motor control, contributes to preparatory activity in the neocortex. We review recent advances and offer perspective on the function of cortico-cerebellar interactions during goal-directed behavior. We propose that the cerebellum learns to facilitate transitions between neocortical activity states. Transitions between activity states enable flexible and appropriately timed behavioral responses.
| Type: | Article |
|---|---|
| Title: | Cortico-cerebellar interactions during goal-directed behavior |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.conb.2020.08.010 |
| Publisher version: | https://doi.org/10.1016/j.conb.2020.08.010 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10112715 |
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