UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Stroke: causes and clinical features

Murphy, SJX; Werring, DJ; (2020) Stroke: causes and clinical features. Medicine , 48 (9) pp. 561-566. 10.1016/j.mpmed.2020.06.002. Green open access

[thumbnail of Werring_stroke causes and clinical features FINAL CLEAN.pdf]
Preview
Text
Werring_stroke causes and clinical features FINAL CLEAN.pdf - Accepted Version

Download (607kB) | Preview

Abstract

Stroke is a clinically defined syndrome of acute, focal neurological deficit attributed to vascular injury (infarction, haemorrhage) of the central nervous system. Stroke is the second leading cause of death and disability worldwide. Stroke is not a single disease but can be caused by a wide range of risk factors, disease processes and mechanisms. Hypertension is the most important modifiable risk factor for stroke, although its contribution differs for different subtypes. Most (85%) strokes are ischaemic, predominantly caused by small vessel arteriolosclerosis, cardioembolism and large artery athero-thromboembolism. Ischaemic strokes in younger patients can result from a different spectrum of causes such as extracranial dissection. Approximately 15% of strokes worldwide are the result of intracerebral haemorrhage, which can be deep (basal ganglia, brainstem), cerebellar or lobar. Deep haemorrhages usually result from deep perforator (hypertensive) arteriopathy (arteriolosclerosis), while lobar haemorrhages are mainly caused by cerebral amyloid angiopathy or arteriolosclerosis. A minority (about 20%) of intracerebral haemorrhages are caused by macrovascular lesions (vascular malformations, aneurysms, cavernomas), venous sinus thrombosis or rarer causes; these are particularly important in young patients (<50 years). Knowledge of vascular and cerebral anatomy is important in localizing strokes and understanding their mechanisms. This guides rational acute management, investigation, and secondary prevention.

Type: Article
Title: Stroke: causes and clinical features
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2020.06.002
Publisher version: https://doi.org/10.1016/j.mpmed.2020.06.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cerebrovascular disease, MRCP, intracerebral haemorrhage, ischaemic stroke, stroke pathogenesis, stroke risk factors, transient ischaemic attack
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10112606
Downloads since deposit
720Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item