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Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation

Kurteva, E; Bamford, A; Cross, K; Watson, T; Owens, C; Cheng, F; Hartley, J; ... Köglmeier, J; + view all (2020) Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation. Frontiers in Pediatrics , 8 , Article 142. 10.3389/fped.2020.00142. Green open access

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Abstract

Basidiobolomycosis is a rare fungal disease caused by Basidiobolus ranarum. Involvement of the gastrointestinal tract is unusual and poses both a diagnostic and therapeutic challenge, as clinical signs are non-specific and predisposing risk factors are lacking. It can mimick inflammatory bowel disease, primary immunodeficiency, or a malignancy and should be considered in patients who do not respond to standard therapy. We present the case of a 22 months old boy with confirmed colonic Basidiobolomycosis, who presented with severe eosinophilic inflammation of the gastrointestinal tract. Panfungal PCR performed on DNA extracted directly from a tissue sample confirmed the presence of Basidiobolus. He made a full recovery with a combination of surgery and prolonged targeted antifungal medication.

Type: Article
Title: Colonic Basidiobolomycosis—An Unusual Presentation of Eosinophilic Intestinal Inflammation
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fped.2020.00142
Publisher version: http://dx.doi.org/10.3389/fped.2020.00142
Language: English
Additional information: © 2020 Kurteva, Bamford, Cross, Watson, Owens, Cheng, Hartley, Harris, Johnson, Lindley, Levine and Köglmeier. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: basidiobolomycosis, children, colon, eosinophilic inflammation, intestine
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10112360
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