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Quantitative assessment of terminal ileum motility on MR enterography in Crohn disease: a feasibility study in children

Cococcioni, L; Fitzke, H; Menys, A; Gaunt, T; Kumar, S; Kiparissi, F; Rampling, D; ... Watson, TA; + view all (2021) Quantitative assessment of terminal ileum motility on MR enterography in Crohn disease: a feasibility study in children. European Radiology , 31 pp. 775-784. 10.1007/s00330-020-07084-1. Green open access

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Abstract

Objectives: Investigate the relationship between quantified terminal ileal (TI) motility and histopathological activity grading, Crohn Disease MRI Index (CDMI) and faecal calprotectin. / Methods: Retrospective review of children with Crohn disease or unclassified inflammatory bowel disease, who underwent MR enterography. Dynamic imaging for 25 patients (median age 12, range 5 to 16) was analysed with a validated motility algorithm. The TI motility score was derived. The primary reference standard was TI Endoscopic biopsy Assessment of Inflammatory Activity (eAIS) within 40 days of the MR enterography. Secondary reference standards: (1) the Crohn Disease MRI Index (CDMI) and (2) faecal calprotectin levels. / Results: MR enterography median motility score was 0.17 a.u. (IQR 0.12 to 0.25; range 0.05 to 0.55), and median CDMI was 3 (IQR 0 to 5.5). Forty-three percent of patients had active disease (eAIS > 0) with a median eAIS score of 0 (IQR 0 to 2; range 0 to 5). The correlation between eAIS and motility was r = − 0.58 (p = 0.004, N = 23). Between CDMI and motility, r = − 0.42 (p = 0.037, N = 25). Motility score was lower in active disease (median 0.12 vs 0.21, p = 0.020) while CDMI was higher (median 5 vs 1, p = 0.04). In a subset of 12 patients with faecal calprotectin within 3 months of MR enterography, correlation with motility was r = − 0.27 (p = 0.4). / Conclusions: Quantified terminal ileum motility decreases with increasing histopathological abnormality in children with Crohn disease, reproducing findings in adults. TI motility showed a negative correlation with an MRI activity score but not with faecal calprotectin levels.

Type: Article
Title: Quantitative assessment of terminal ileum motility on MR enterography in Crohn disease: a feasibility study in children
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00330-020-07084-1
Publisher version: https://doi.org/10.1007/s00330-020-07084-1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Functional magnetic resonance imaging, Paediatric, Crohn disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10112268
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