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A genome-wide association and replication study of blood pressure in Ugandan early adolescents

Lule, SA; Mentzer, AJ; Namara, B; Muwenzi, AG; Nassanga, B; Kizito, D; Akurut, H; ... Webb, EL; + view all (2019) A genome-wide association and replication study of blood pressure in Ugandan early adolescents. Molecular Genetics & Genomic Medicine , 7 (10) , Article e00950. 10.1002/mgg3.950. Green open access

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Abstract

Background: Genetic association studies of blood pressure (BP) have mostly been conducted in non‐African populations. Using the Entebbe Mother and Baby Study (EMaBS), we aimed to identify genetic variants associated with BP among Ugandan adolescents. / Methods: Systolic and diastolic BP were measured among 10‐ and 11‐year olds. Whole‐genome genotype data were generated using Illumina omni 2.5M arrays and untyped variants were imputed. Genome‐wide association study (GWAS) was conducted using linear mixed model regression to account for population structure. Linear regression analysis was used to assess whether variants previously associated with BP (p < 5.0 × 10−8) in published BP GWASs were replicated in our study. / Results: Of the 14 million variants analyzed among 815 adolescents, none reached genome‐wide significance (p < 5.0×10−8) for association with systolic or diastolic BP. The most strongly associated variants were rs181430167 (p = 6.8 × 10−7) for systolic BP and rs12991132 (p = 4.0 × 10−7) for diastolic BP. Thirty‐three (17 single nucleotide polymorphisms (SNPs) for systolic BP, 15 SNPs for diastolic BP and one SNP for both) of 330 variants previously identified as associated with BP were replicated in this study, but none remained significant after accounting for multiple testing. / Conclusion: Variants showing suggestive associations are worthy of future investigation. Replication results suggest that variants influencing adolescent BP may overlap somewhat with those already established in previous studies, largely based on adults in Western settings.

Type: Article
Title: A genome-wide association and replication study of blood pressure in Ugandan early adolescents
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mgg3.950
Publisher version: https://doi.org/10.1002/mgg3.950
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, adolescents, Africa, blood pressure, genetics, replication analysis, single nucleotide polymorphisms, Uganda, COMMON VARIANTS, AFRICAN-AMERICANS, GENETIC-VARIATION, LOCI, HYPERTENSION, TRAITS, METAANALYSIS, INDIVIDUALS, POPULATIONS, DISCOVERY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/10112199
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