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Designing peptide nanoparticles for efficient brain delivery

Duro-Castano, A; Leite, DM; Forth, J; Deng, Y; Matias, D; Jesus, CN; Battaglia, G; (2020) Designing peptide nanoparticles for efficient brain delivery. Advanced Drug Delivery Reviews , 160 pp. 52-77. 10.1016/j.addr.2020.10.001. Green open access

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Abstract

The targeted delivery of therapeutic compounds to the brain is arguably the most significant open problem in drug delivery today. Nanoparticles (NPs) based on peptides and designed using the emerging principles of molecular engineering show enormous promise in overcoming many of the barriers to brain delivery faced by NPs made of more traditional materials. However, shortcomings in our understanding of peptide self-assembly and blood–brain barrier (BBB) transport mechanisms pose significant obstacles to progress in this area. In this review, we discuss recent work in engineering peptide nanocarriers for the delivery of therapeutic compounds to the brain, from synthesis, to self-assembly, to in vivo studies, as well as discussing in detail the biological hurdles that a nanoparticle must overcome to reach the brain.

Type: Article
Title: Designing peptide nanoparticles for efficient brain delivery
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.addr.2020.10.001
Publisher version: https://doi.org/10.1016/j.addr.2020.10.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, Blood–brain barrier, Drug delivery, Glioma, Parkinson’s disease, Peptides, Self-assembly, Transcytosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10112171
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