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CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

Walls, GM; Oughton, JB; Chalmers, AJ; Brown, S; Collinson, F; Forster, MD; Franks, KN; ... Greystoke, A; + view all (2020) CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer. Clinical and Translational Radiation Oncology , 25 pp. 61-66. 10.1016/j.ctro.2020.09.006. Green open access

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Abstract

Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for ‘gold standard’ treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding.

Type: Article
Title: CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ctro.2020.09.006
Publisher version: https://doi.org/10.1016/j.ctro.2020.09.006
Language: English
Additional information: © 2020 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10112165
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