Walls, GM;
Oughton, JB;
Chalmers, AJ;
Brown, S;
Collinson, F;
Forster, MD;
Franks, KN;
... Greystoke, A; + view all
(2020)
CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer.
Clinical and Translational Radiation Oncology
, 25
pp. 61-66.
10.1016/j.ctro.2020.09.006.
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Abstract
Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for ‘gold standard’ treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding.
| Type: | Article |
|---|---|
| Title: | CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ctro.2020.09.006 |
| Publisher version: | https://doi.org/10.1016/j.ctro.2020.09.006 |
| Language: | English |
| Additional information: | © 2020 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10112165 |
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