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Characterization of B₀-field fluctuations in prostate MRI

Kakkar, LS; Usman, M; Arridge, S; Kirkham, A; Atkinson, D; (2020) Characterization of B₀-field fluctuations in prostate MRI. Physics in Medicine & Biology 10.1088/1361-6560/abbc7f. (In press). Green open access

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Kakkar+et+al_2020_Phys._Med._Biol._10.1088_1361-6560_abbc7f.pdf - Accepted version

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Abstract

Multi-parametric MRI is increasingly used for prostate cancer detection. Improving information from current sequences, such as T2-weighted and diffusion-weighted (DW) imaging, and additional sequences, such as magnetic resonance spectroscopy (MRS) and chemical exchange saturation transfer (CEST), may enhance the performance of multi-parametric MRI. The majority of these techniques are sensitive to B0-field variations and may result in image distortions including signal pile-up and stretching (echo planar imaging (EPI) based DW-MRI) or unwanted shifts in the frequency spectrum (CEST and MRS). Our aim is to temporally and spatially characterize B0-field changes in the prostate. Ten male patients are imaged using dual-echo gradient echo sequences with varying repetitions on a 3T scanner to evaluate the temporal B0-field changes within the prostate. A phantom is also imaged to consider no physiological motion. The spatial B0-field variations in the prostate are reported as B0-field values (Hz), their spatial gradients (Hz/mm) and the resultant distortions in EPI based DW-MRI images (b-value = 0 s/mm2and two oppositely phase encoded directions). Over a period of minutes, temporal changes in B0-field values were ≤19 Hz for minimal bowel motion and ≥30 Hz for large motion. Spatially across the prostate, the B0-field values had an interquartile range of ≤18 Hz (minimal motion) and ≤44 Hz (large motion). The B$_0$-field gradients were between -2 and 5 Hz/mm (minimal motion) and 2 to 12 Hz/mm (large motion). Overall, B0-field variations can affect DW, MRS and CEST imaging of the prostate.

Type: Article
Title: Characterization of B₀-field fluctuations in prostate MRI
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1361-6560/abbc7f
Publisher version: https://doi.org/10.1088/1361-6560/abbc7f
Language: English
Additional information: © Copyright 2020 IOP Publishing. As the Version of Record of this article is going to be/has been published on a gold open access basis under a CC BY 3.0 licence, this Accepted Manuscript is available for reuse under a CC BY 3.0 licence immediately (https://creativecommons.org/licenses/by/3.0/).
Keywords: CEST, MRS, diffusion MRI, mpMRI, prostate MRI, prostate phantom
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10112159
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