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Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone) and ketoprofen

Geng, Y; Zhou, F; Williams, GR; (2020) Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone) and ketoprofen. Journal of Drug Delivery Science and Technology (102138) 10.1016/j.jddst.2020.102138. (In press).

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Abstract

Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20 mL/h. The fibers all took the shape of cylinders and had smooth surfaces. They comprise amorphous solid dispersions of drug-in-polymer, with very high drug encapsulation efficiencies (100%). With a low drug loading (9.09% w/w) the electrospun materials could disintegrate quickly and accelerate the dissolution profile of ketoprofen under non-sink conditions representative of the oral cavity. However, at higher loadings (23.08% w/w), this benefit is no longer realized, indicating that there is a maximum drug loading above which the dissolution-enhancing properties of the amorphous form and the hydrophilic PVP carrier cease to be effective. After storage under ambient conditions (19–21 °C, relative humidity 30–40%) for 4 weeks, the formulations remained amorphous, with no significant changes in their drug release properties. Very similar behaviour in terms of drug release and storage stability was seen regardless of the throughput rate used for fiber fabrication, showing the potential to rapidly produce large amounts of high-performing material.

Type: Article
Title: Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone) and ketoprofen
DOI: 10.1016/j.jddst.2020.102138
Publisher version: https://doi.org/10.1016/j.jddst.2020.102138
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Electrospinning, PVP, Ketoprofen, Oral fast dissolving drug delivery system
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10111836
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