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The role of aspirin in the prevention of ovarian, endometrial and cervical cancers

Joharatnam-Hogan, N; Cafferty, FH; Macnair, A; Ring, A; Langley, RE; (2020) The role of aspirin in the prevention of ovarian, endometrial and cervical cancers. Women's Health , 16 10.1177/1745506520961710. Green open access

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Abstract

Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely accessible therapies. A large body of evidence supports the role of aspirin as an anti-cancer agent, and a number of randomized trials are currently underway aiming to assess the potential benefit of aspirin in the treatment of cancer. This review summarizes the evidence underpinning aspirin use for the prevention of the development and recurrence of gynaecological cancers (ovarian, endometrial and cervical) and potential mechanisms of action.

Type: Article
Title: The role of aspirin in the prevention of ovarian, endometrial and cervical cancers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1745506520961710
Publisher version: https://doi.org/10.1177%2F1745506520961710
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Aspirin, cervical cancer, endometrial cancer, ovarian cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10111614
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