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A linkage study of chromosome 5q11.2-q13.3 in schizophrenia

Sherrington, Robin Paul; (1992) A linkage study of chromosome 5q11.2-q13.3 in schizophrenia. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Early studies investigating the inheritance of schizophrenia estimated that between 66% to 93% of the variance in the aetiology is genetic. However, segregation analysis studying the patterns of affected individuals within families has not been able to establish a common mode of transmission. Nevertheless linkage analysis of marker data obtained from families is considered to be the most efficient and robust approach to studying the genetic aetiology of schizophrenia. Linkage studies in schizophrenia can be directed towards regions of the genome where there is a priori grounds for the presence of a susceptibility locus. This study investigated chromosome 5 after a report of an association (though weak) between a partial trisomy of chromosome 5q 11.2-q13.3 and schizophrenia.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: A linkage study of chromosome 5q11.2-q13.3 in schizophrenia
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
Keywords: Biological sciences; Schizophrenia
URI: https://discovery.ucl.ac.uk/id/eprint/10111503
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