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An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)

Facchinetti, F; Cavalli, P; Copp, AJ; D'Anna, R; Kandaraki, E; Greene, NDE; Unfer, V; (2020) An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opinion on Drug Metabolism & Toxicology , 16 (12) pp. 1189-1198. 10.1080/17425255.2020.1828344. Green open access

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Abstract

INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.

Type: Article
Title: An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/17425255.2020.1828344
Publisher version: http://dx.doi.org/10.1080/17425255.2020.1828344
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: D-chiro-inositol (DCI), gestational diabetes mellitus (GDM), insulin resistance, myo-inositol (MI), neural tube defects (NTDs), prevention
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10111454
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