Facchinetti, F;
Cavalli, P;
Copp, AJ;
D'Anna, R;
Kandaraki, E;
Greene, NDE;
Unfer, V;
(2020)
An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs).
Expert Opinion on Drug Metabolism & Toxicology
, 16
(12)
pp. 1189-1198.
10.1080/17425255.2020.1828344.
Preview |
Text
An update on the use of inositols in preventing gestational diabetes mellitus GDM and neural tube defects NTDs.pdf - Accepted Version Download (1MB) | Preview |
Abstract
INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.
| Type: | Article |
|---|---|
| Title: | An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs) |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/17425255.2020.1828344 |
| Publisher version: | http://dx.doi.org/10.1080/17425255.2020.1828344 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | D-chiro-inositol (DCI), gestational diabetes mellitus (GDM), insulin resistance, myo-inositol (MI), neural tube defects (NTDs), prevention |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111454 |
Archive Staff Only
 |
View Item |
