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Endocannabinoid system alterations in Alzheimer's disease: a systematic review of human studies

Berry, AJ; Zubko, O; Reeves, SJ; Howard, RJ; (2020) Endocannabinoid system alterations in Alzheimer's disease: a systematic review of human studies. Brain Research , 1749 , Article 147135. 10.1016/j.brainres.2020.147135. Green open access

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Abstract

Studies investigating alterations of the endocannabinoid system (ECS) in Alzheimer's disease (AD) in humans have reported inconsistent findings so far. We performed a systematic review of studies examining alterations of the ECS specifically within humans with AD or mild cognitive impairment (MCI), including neuroimaging studies, studies of serum and cerebrospinal fluid biomarkers, and post-mortem studies. We attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (AEA); 2-arachidonoylglycerol (2-AG); monoacylglycerol lipase (MAGL); fatty acid amide hydrolase (FAAH); and transient receptor potential cation channel V1 (TRPV1). Twenty-two studies were identified for inclusion. Mixed findings were reported for most aspects of the ECS in AD, making it difficult to identify a particular profile of ECS alterations characterising AD. The included studies tended to be small, methodologically heterogeneous, and frequently did not control for important potential confounders, such as pathological progression of AD. Eight studies correlated ECS alterations with neuropsychometric performance measures, though studies infrequently examined behavioural and neuropsychiatric correlates. PROSPERO database identifier: CRD42018096249.

Type: Article
Title: Endocannabinoid system alterations in Alzheimer's disease: a systematic review of human studies
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.brainres.2020.147135
Publisher version: https://doi.org/10.1016/j.brainres.2020.147135
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: 2-arachidonoylglycerol, Alzheimer, TRPV1, anandamide, cannabinoid receptor, endocannabinoid, fatty acid amide hydrolase, monoacylglycerol, neurodegeneration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10111422
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