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Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

Liu, M; Apriceno, A; Sipin, M; Scarpa, E; Rodriguez-Arco, L; Poma, A; Marchello, G; ... Angioletti-Uberti, S; + view all (2020) Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions. Nature Communications , 11 (1) , Article 4836. 10.1038/s41467-020-18603-5. Green open access

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Abstract

From viruses to nanoparticles, constructs functionalized with multiple ligands display peculiar binding properties that only arise from multivalent effects. Using statistical mechanical modelling, we describe here how multivalency can be exploited to achieve what we dub range selectivity, that is, binding only to targets bearing a number of receptors within a specified range. We use our model to characterise the region in parameter space where one can expect range selective targeting to occur, and provide experimental support for this phenomenon. Overall, range selectivity represents a potential path to increase the targeting selectivity of multivalent constructs.

Type: Article
Title: Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-020-18603-5
Publisher version: https://doi.org/10.1038/s41467-020-18603-5
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Biophysical chemistry, Drug delivery, Scaling laws
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10111282
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