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Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Eleftheriadou, D; Kesidou, D; Moura, F; Felli, E; Song, W; (2020) Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases. Small , Article 1907308. 10.1002/smll.201907308. (In press). Green open access

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Abstract

Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeutic approaches have been suggested so far to improve the endogenous defense against oxidative stress and its harmful effects. Among such approaches, the use of artificial antioxidant systems has gained increased popularity as an effective strategy. Nanoscale drug delivery systems loaded with enzymes, bioinspired catalytic nanoparticles and other nanomaterials have emerged as promising candidates. The development of degradable hydrogels scaffolds with antioxidant effects could also enable scientists to positively influence cell fate. This current review summarizes nanobiomaterial‐based approaches for redox regulation and their potential applications as central nervous system neurodegenerative disease treatments.

Type: Article
Title: Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/smll.201907308
Publisher version: https://doi.org/10.1002/smll.201907308
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10111156
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