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Extracellular vesicles can be processed by electrospinning without loss of structure or function

Trindade, RP; Renault, N; Harane, NE; Menasché, P; Williams, GR; (2021) Extracellular vesicles can be processed by electrospinning without loss of structure or function. Materials Letters , 282 , Article 128671. 10.1016/j.matlet.2020.128671.

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Abstract

Extracellular vesicles (EVs) are cell-derived bodies proven to have a wide range of therapeutic applications. To date, EVs have almost always been administered by direct injection, which is very likely to hinder their efficacy because of rapid clearance from the injection site. Here we show that EVs can be successfully processed into polymer-based fibres by electrospinning, with no loss of structure or function.

Type: Article
Title: Extracellular vesicles can be processed by electrospinning without loss of structure or function
DOI: 10.1016/j.matlet.2020.128671
Publisher version: https://doi.org/10.1016/j.matlet.2020.128671
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Electrospinning, Nanofibres, Extracellular vesicles, Tissue regeneration
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10110801
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