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Cognitive impairment in multiple sclerosis: clinical and nuclear magnetic resonance imaging correlates

Callanan-Kelsey, Margaret Mary; (1990) Cognitive impairment in multiple sclerosis: clinical and nuclear magnetic resonance imaging correlates. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Fifty-eight patients with Clinically Definite Multiple Sclerosis (MS) and forty-eight patients with clinically isolated lesions (CIL) of the kind frequently observed in MS, were psychometrically examined with a range of neuropsychological tests. The results were examined in conjunction with Magnetic Resonance Imaging (MRI), neurological, psychiatric and physical ability evidence and compared to a matched group of forty-six controls. A method is described for calculating the overall cognitive efficiency of each individual and this measure is examined in relation to MRI, neurological, psychiatric and motor ability evidence. Measures of the cognitive speed of memory and object-naming are examined and the relationship between accuracy and speed on these functions is explored. The MS group present with intact accuracy on Verbal Recognition Memory and Object-naming while demonstrating slowed cognitive processing in both functions. The CIL group also present with intact accuracy on these functions and, in addition. Abstracting Ability and accuracy of Visual Recognition Memory are intact: however, CIL patients demonstrate slowed cognitive processing on Visual Recognition Memory, as do the MS group. Dissociation between speed and accuracy was observed for MS and CIL patients and this is discussed with regard to the concept of 'subcortical' dementia. The interaction of speed with accuracy is different between the three groups with the CIL group occupying the intermediate level. Impairment of function within the MS group is demonstrated to be related to lesions observed on MRI. Cognitive impairment within the CIL group, however, was not established as a correlate of MRI lesions but would seem to relate to disease status. The results of the present study present evidence of impairment of cognitive efficiency and cognitive speed in patients with MS and in CIL patients. The level of impairment of the CIL group is intermediate when compared to that of the MS group and the controls.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Cognitive impairment in multiple sclerosis: clinical and nuclear magnetic resonance imaging correlates
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
Keywords: Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10110696
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