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Development and validation of the “Addenbrooke’s Cognitive Examination” as a screening Test for mild cognitive impairment in hearing Impaired individuals

North, Courtney; (2020) Development and validation of the “Addenbrooke’s Cognitive Examination” as a screening Test for mild cognitive impairment in hearing Impaired individuals. Doctoral thesis (D.Clin.Psy), UCL (University College London). Green open access

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Abstract

Background: Despite high comorbidity of age-related hearing loss in individuals with mild cognitive impairment (MCI), current tests are inadequate to screen for MCI in hearing-impaired populations. Objectives: To develop a hearing-impaired version of the Addenbrooke’s Cognitive Examination (HI-ACE-III) and assess whether it can be used as a screening tool for mild cognitive impairment (MCI), and accurately distinguish cognitively impaired people from healthy controls. Method: In consultation with specialist neuropsychologists and older adults, the HI-ACE-III was developed by converting verbal instructions into a timed, visual PowerPoint (Microsoft Corp.) presentation. Two groups of subjects over the age of 60 were recruited; 29 had MCI and 30 were healthy controls. The HI-ACE-III was administered to both groups in order to establish diagnostic accuracy. the Rey-Osterrieth Complex Figure (ROFC), Spatial Span (SS) and Graded Naming Test (GNT), which are established non-hearing dependent measures, were also administered to assess convergent and divergent validity, Results: A Receiver Operating Characteristic (ROC) analysis revealed an Area Under the Curve (AUC) of 0.856, achieving reasonable sensitivity (75.9%) and good specificity (86.7%) at an optimum cut-off of <92. All HI-ACE-III subtests shared statistically significant correlations with the other measures of cognitive functioning. Internal consistency of the HI-ACE-III was verified with Cronbach’s alpha (α = .819). Conclusions: The results indicate that the HI-ACE-III is a sensitive and specific screening tool, with a good ability to diagnose patients with and without MCI. It is an easy to use adaptation of an already familiar tool, which clinicians who screen for MCI in hearing impaired groups, could use to promptly identify individuals who might benefit from more extensive neuropsychological investigation.

Type: Thesis (Doctoral)
Qualification: D.Clin.Psy
Title: Development and validation of the “Addenbrooke’s Cognitive Examination” as a screening Test for mild cognitive impairment in hearing Impaired individuals
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10110585
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