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Lanthanide [Terbium(III)]-Doped Molecularly Imprinted Nanoarchitectures for the Fluorimetric Detection of Melatonin

Özgür, E; Patra, HK; Turner, APF; Denizli, A; Uzun, L; (2020) Lanthanide [Terbium(III)]-Doped Molecularly Imprinted Nanoarchitectures for the Fluorimetric Detection of Melatonin. Industrial & Engineering Chemistry Research , 59 (36) pp. 16068-16076. 10.1021/acs.iecr.0c02387. Green open access

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Abstract

Polymerizable terbium(III) complex-based fluorescent molecular imprinted smart nanoparticles were synthesized for the quantitative determination of potential metabolic destitution biomarkers. Melatonin has been reported to be one of the key factors in seasonal affective disorder (SAD) and was chosen as a model metabolite to demonstrate a novel molecularly imprinted polymer (MIP) nanoparticle sensor. We exploited lanthanide ion complexes in our biosensing platforms due to their deeper penetration ability, negligible autofluorescence, lack of photobleaching and photoblinking, and their sharp absorption and emission bands, extreme photostability, and long lifetime. Given the high affinity of lanthanide ions for carboxylic acid groups, we used two amino acid-based functional monomers, N-methacryloyl-l-tryptophan and N-methacryloyl-l-aspartic acid, to coordinate terbium(III) ions and melatonin, respectively. The fluorescent MIP nanoparticles were synthesized using a miniemulsion polymerization technique after forming complexes between terbium(III):MA-Asp and melatonin:MATrp molecules. Due to the polymerizability of lanthanide complexes, they were readily inserted into the polymeric chain, which enabled homogeneous distribution as well as closer orientation to the imprinted cavities for selective melatonin recognition.

Type: Article
Title: Lanthanide [Terbium(III)]-Doped Molecularly Imprinted Nanoarchitectures for the Fluorimetric Detection of Melatonin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.iecr.0c02387
Publisher version: https://doi.org/10.1021/acs.iecr.0c02387
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Monomers, Fluorescence, Molecules, Ions, Selectivity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10110580
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