UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Circulating metabolites are associated with brain atrophy and white matter hyperintensities

de Leeuw, FA; Karamujić-Čomić, H; Tijms, BM; Peeters, CFW; Kester, MI; Scheltens, P; Ahmad, S; ... van der Flier, WM; + view all (2020) Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimer's & Dementia 10.1002/alz.12180. Green open access

[thumbnail of alz.12180.pdf]
Preview
Text
alz.12180.pdf - Published Version

Download (912kB) | Preview

Abstract

INTRODUCTION: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). METHODS: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. RESULTS: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. DISCUSSION: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.

Type: Article
Title: Circulating metabolites are associated with brain atrophy and white matter hyperintensities
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/alz.12180
Publisher version: http://dx.doi.org/10.1002/alz.12180
Language: English
Additional information: © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Keywords: Alzheimer's disease, cholesterol, glucose, lipids, magnetic resonance imaging (MRI), metabolism
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10110467
Downloads since deposit
48Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item