UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Increased blood–brain barrier permeability to water in the aging brain detected using noninvasive multi‐TE ASL MRI

Ohene, Y; Harrison, IF; Evans, PG; Thomas, DL; Lythgoe, MF; Wells, JA; (2020) Increased blood–brain barrier permeability to water in the aging brain detected using noninvasive multi‐TE ASL MRI. Magnetic Resonance in Medicine 10.1002/mrm.28496. (In press). Green open access

[thumbnail of 2020 Ohene et al., MRM.pdf]
Preview
Text
2020 Ohene et al., MRM.pdf - Published Version

Download (453kB) | Preview

Abstract

PURPOSE: A fundamental goal in the drive to understand and find better treatments for dementia is the identification of the factors that render the aging brain vulnerable to neurodegenerative disease. Recent evidence indicates the integrity of the blood-brain barrier (BBB) to be an important component of functional failure underlying age-related cognitive decline. Practical and sensitive measurement is necessary, therefore, to support diagnostic and therapeutic strategies targeted at maintaining BBB integrity in aging patients. Here, we investigated changes in BBB permeability to endogenous blood water in the aging brain. METHODS: A multiple-echo-time arterial spin-labeling MRI technique, implemented on a 9.4T Bruker imaging system, was applied to 7- and 27-month-old mice to measure changes in water permeability across the BBB with aging. RESULTS: We observed that BBB water permeability was 32% faster in aged mice. This occurred along with a 2.1-fold increase in mRNA expression of aquaporin-4 water channels and a 7.1-fold decrease in mRNA expression of α-syntrophin protein, which anchors aquaporin-4 to the BBB. CONCLUSION: Age-related changes to water permeability across the BBB can be captured using noninvasive noncontrast MRI techniques.

Type: Article
Title: Increased blood–brain barrier permeability to water in the aging brain detected using noninvasive multi‐TE ASL MRI
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.28496
Publisher version: https://onlinelibrary.wiley.com/doi/10.1002/mrm.28...
Language: English
Additional information: Copyright © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: aging, aquaporin-4, arterial spin labeling, blood-brain barrier, blood-brain interface, water permeability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10110282
Downloads since deposit
123Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item