UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cranial findings detected by second trimester ultrasound in fetuses with myelomeningocele: a systematic review

Kunpalin, Y; Richter, J; Mufti, N; Bosteels, J; Ourselin, S; De Coppi, P; Thompson, D; ... Deprest, J; + view all (2021) Cranial findings detected by second trimester ultrasound in fetuses with myelomeningocele: a systematic review. BJOG , 128 (2) pp. 366-374. 10.1111/1471-0528.16496. Green open access

[img]
Preview
Text
David_PDFsam_David_1471-0528.16496.pdf - Published version

Download (786kB) | Preview

Abstract

BACKGROUND: Abnormal intracranial findings are often detected at mid-trimester ultrasound (US) in fetuses with MMC. It is unclear whether these findings constitute a spectrum of the disease or are an independent finding, which should contraindicate fetal surgery. OBJECTIVE: To ascertain the spectrum and frequency of US detected cranial findings in MMC fetuses. SEARCH STRATEGY: MEDLINE, Embase, Web of Science and CENTRAL search, January 2000-June 2020. SELECTION CRITERIA: Study reporting incidence of cranial US findings in consecutive cases of second trimester MMC fetuses. DATA COLLECTION AND ANALYSIS: Publication quality was assessed by NOS and modified NOS. Meta-analysis could not be performed due to high clinical diversity and study heterogeneity. RESULTS: 14 cranial US findings were reported in 15 studies. Findings in classic Chiari II malformation (CIIM) spectrum included posterior fossa funnelling (96%), small transcerebellar diameter (82-96%), 'banana' sign (50-100%), beaked tectum (65%) and 'lemon' sign (53-100%). Additional cranial findings were small BPD and HC (<5th centile; 53% and 71%, respectively), ventriculomegaly (45-89%), abnormal pointed-shape of the occipital horn (77-78%), thinning of the posterior cerebrum, perinodular heterotopia (11%), abnormal gyration (3%), corpus callosum disorders (60%) and midline interhemispheric cyst (42%). CONCLUSIONS: We identified 14 cranial findings by second trimester US in MMC fetuses. The relatively high incidence of these findings and their unclear prognostic significance might not contraindicate fetal surgery in the case of normal fetal genetic testing. Some cranial findings however may independently impact postnatal outcome. Long-term detailed follow up is required to investigate this.

Type: Article
Title: Cranial findings detected by second trimester ultrasound in fetuses with myelomeningocele: a systematic review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.16496
Publisher version: https://doi.org/10.1111/1471-0528.16496
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Chiari II malformation, Myelomeningocele, Spina bifida, Spinal dysraphism, fetal surgery, prenatal, spina bifida aperta, ultraso
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10110262
Downloads since deposit
38Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item