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On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it

Xiao, B; Zhou, X; Xu, H; Zhang, W; Xu, X; Tian, F; Qian, Y; ... Shen, Y; + view all (2020) On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it. Biomaterials Science , 8 (18) pp. 5210-5218. 10.1039/d0bm00842g. Green open access

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Abstract

Nanotechnology has a remarkable impact on the preclinical development of future medicines. However, the complicated preparation and systemic toxicity to living systems prevent them from translation to clinical applications. In the present report, we developed a polyepicatechin-based on/off switchable ultra-sensitive magnetic resonance imaging (MRI) visible theranostic nanoparticle (PEMN) for image-guided photothermal therapy (PTT) using our strategy of integrating polymerization and biomineralization into the protein template. We have exploited natural polyphenols as the near infra-red (NIR) switchable photothermal source and MnO2 for the MRI-guided theranostics. PEMN demonstrates excellent MRI contrast ability with a longitudinal relaxivity value up to 30.01 mM−1 s−1. PEMN has shown great tumor inhibition on orthotopic breast tumors and the treatment could be made switchable with an on/off interchangeable mode as needed. PEMN was found to be excretable mainly through the kidneys, avoiding potential systemic toxicity. Thus, PEMN could be extremely useful for developing on-demand therapeutics via ‘see it and treat it’ means with distinguished MRI capability and on/off switchable photothermal properties.

Type: Article
Title: On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d0bm00842g
Publisher version: https://doi.org/10.1039/d0bm00842g
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10110248
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