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Pathological Mineralisation

Tsolaki, Elena; (2020) Pathological Mineralisation. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Pathological mineralisation is a well-known phenomenon in the medical field as it relates to a wide range of diseases, including cancer, neurodegenerative dis-eases, aortic valve stenosis, and atherosclerosis. Despite this, the direct study of pathological minerals has been rare, as most research focuses on the study of the organic components of these pathologies and the microenvironment the minerals are observed in. Even though material science methods have been used for the study of biomaterials, hard tissues, and other biological systems; they have not been widely used in the research of pathological mineralisation. This work is, subsequently, con-centrating on the direct study of the minerals found in cardiovascular, breast, and brain tissues aiming to provide a full physicochemical characterization. The presence of in-organic material in these soft tissues has been long observed in relation to several diseases, but the relationship between their properties and specific pathologies is not fully understood. Therefore, through the direct investigation of the minerals present, this study aims to provide new insights into the association of unique mineral proper-ties to specific disease characteristics. In addition, the data on the mineral properties will then be evaluated to gain information on the mineral formation processes, in order to identify proteins, cells, or vesicles, which might be involved. Finally, a range of bio-chemical assays will be used, aiming to directly investigate the presence of biological markers in the inorganic material to give new insights on the mineralisation mecha-nisms.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Pathological Mineralisation
Event: UCL
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10109711
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