Machhada, A;
Hosford, PS;
Dyson, A;
Ackland, GL;
Mastitskaya, S;
Gourine, AV;
(2020)
Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure.
JACC: Basic to Translational Science
, 5
(8)
pp. 799-810.
10.1016/j.jacbts.2020.06.002.
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Abstract
Large clinical trials designed to test the efficacy of vagus nerve stimulation (VNS) in patients with heart failure did not demonstrate benefits with respect to the primary endpoints. The nonselective nature of VNS may account for the failure to translate promising results of preclinical and earlier clinical studies. This study showed that optogenetic stimulation of vagal pre-ganglionic neurons transduced to express light-sensitive channels preserved left ventricular function and exercise capacity in a rat model of myocardial infarction-induced heart failure. These data suggested that stimulation of vagal efferent activity is critically important to deliver the therapeutic benefit of VNS in heart failure.
| Type: | Article |
|---|---|
| Title: | Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jacbts.2020.06.002 |
| Publisher version: | https://doi.org/10.1016/j.jacbts.2020.06.002 |
| Language: | English |
| Additional information: | Copyright © 2020 the Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | ABP, arterial blood pressure, DVMN, dorsal motor nucleus of the vagus nerve, GRK2, G-protein−coupled receptor kinase 2, LAD, left anterior descending coronary artery, LV dP/dtMAX, maximum rate of rise of left ventricular pressure, LV, left ventricle, LVEDP, left ventricular end-diastolic pressure, LVESP, left ventricular end-systolic pressure, LVP, left ventricular pressure, LVV, lentiviral vector, MI, myocardial infarction, VNS, vagus nerve stimulation, autonomic nervous system, eGFP, enhanced green fluorescent protein, heart failure, myocardial infarction, neuromodulation, vagus nerve stimulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10109543 |
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