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Different mating contexts lead to extensive rewiring of female brain coexpression networks in the guppy

Bloch, NI; Corral-López, A; Buechel, SD; Kotrschal, A; Kolm, N; Mank, JE; (2021) Different mating contexts lead to extensive rewiring of female brain coexpression networks in the guppy. Genes, Brain and Behavior , 20 (3) , Article e12697. 10.1111/gbb.12697. Green open access

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Abstract

Understanding the basis of behavior requires dissecting the complex waves of gene expression that underlie how the brain processes stimuli and produces an appropriate response. In order to determine the dynamic nature of the neurogenomic network underlying mate choice, we use transcriptome sequencing to capture the female neurogenomic response in two brain regions involved in sensory processing and decision-making under different mating and social contexts. We use differential coexpression (DC) analysis to evaluate how gene networks in the brain are rewired when a female evaluates attractive and non-attractive males, greatly extending current single-gene approaches to assess changes in the broader gene regulatory network. We find the brain experiences a remarkable amount of network rewiring in the different mating and social contexts we tested. Further analysis indicates the network differences across contexts are associated with behaviorally relevant functions and pathways, particularly learning, memory and other cognitive functions. Finally, we identify the loci that display social context-dependent connections, revealing the basis of how relevant neurological and metabolic pathways are differentially recruited in distinct social contexts. More broadly, our findings contribute to our understanding of the genetics of mating and social behavior by identifying gene drivers behind behavioral neural processes, illustrating the utility of DC analysis in neurosciences and behavior.

Type: Article
Title: Different mating contexts lead to extensive rewiring of female brain coexpression networks in the guppy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/gbb.12697
Publisher version: http://dx.doi.org/10.1111/gbb.12697
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Differential network analysis, Gene, Mating behavior - Neurogenomics, Social behavior
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10109460
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