Barnsley, LC;
Gray, MD;
Beguin, E;
Carugo, D;
Stride, E;
(2018)
A Combined Magnetic-Acoustic Device for Simultaneous, Coaligned Application of Magnetic and Ultrasonic Fields.
Advanced Materials Technologies
, 3
(7)
, Article 1800081. 10.1002/admt.201800081.
Preview |
Text
admt.201800081.pdf - Published Version Download (1MB) | Preview |
Abstract
Acoustically‐responsive microbubbles have been widely researched as agents for both diagnostic and therapeutic applications of ultrasound. There has also been considerable interest in magnetically‐functionalised microbubbles as multi‐modality imaging agents and carriers for targeted drug delivery. In this paper, we present a design for an integrated device capable of generating co‐aligned magnetic and acoustic fields in order to accumulate microbubbles at a specific location and to activate them acoustically. For this proof‐of‐concept study, the device was designed to concentrate microbubbles at a distance of 10 mm from the probe's surface, commensurate with relevant tissue depths in preclinical small animal models. Previous studies have indicated that both microbubble concentration and duration of cavitation activity are positively correlated with therapeutic effect. The utility of the device was assessed in vitro tests in a tissue‐mimicking phantom containing a single vessel (1.2 mm diameter). At a peak fluid velocity of 4.2 mm s−1 microbubble accumulation was observed under B‐mode ultrasound imaging and the corresponding cavitation activity was sustained for a period more than 4 times longer than that achieved with an identical acoustic field but in the absence of a magnet. The feasibility of developing a larger scale device for human applications is discussed.
Type: | Article |
---|---|
Title: | A Combined Magnetic-Acoustic Device for Simultaneous, Coaligned Application of Magnetic and Ultrasonic Fields |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/admt.201800081 |
Publisher version: | https://doi.org/10.1002/admt.201800081 |
Language: | English |
Additional information: | © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | drug delivery, magnetic targeting, microbubbles, ultrasound |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery.ucl.ac.uk/id/eprint/10109392 |
Archive Staff Only
![]() |
View Item |