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Sonothrombolysis with Magnetically Targeted Microbubbles

Victor, MDS; Barnsley, LC; Carugo, D; Owen, J; Coussios, CC; Stride, E; (2019) Sonothrombolysis with Magnetically Targeted Microbubbles. Ultrasound in Medicine & Biology , 45 (5) pp. 1151-1163. 10.1016/j.ultrasmedbio.2018.12.014. Green open access

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Abstract

Microbubble-enhanced sonothrombolysis is a promising approach to increasing the tolerability and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site, however, poses a challenge. The objective of this study was to investigate the effect of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral artery. The clots were treated with a combination of tissue plasminogen activator (0.75 µg/mL), magnetic microbubbles (∼10^{7} microbubbles/mL) and ultrasound (0.5 MHz, 630-kPa peak rarefactional pressure, 0.2-Hz pulse repetition frequency, 2% duty cycle). Magnetic targeting was achieved using a single permanent magnet (0.08–0.38 T and 12-140 T/m in the region of the clot). The change in clot diameter was measured optically over the course of the experiment. Magnetic targeting produced a threefold average increase in lysis rates, and linear correlation was observed between lysis rate and total energy of acoustic emissions.

Type: Article
Title: Sonothrombolysis with Magnetically Targeted Microbubbles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ultrasmedbio.2018.12.014
Publisher version: https://doi.org/10.1016/j.ultrasmedbio.2018.12.014
Language: English
Additional information: © 2019 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/).
Keywords: Magnetic targeting, Microbubbles, Thrombolysis, Ultrasound, Clot, Passive cavitation detection, Drug delivery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10109391
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