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ESTRO ACROP guidelines for target volume definition in pancreatic cancer

Brunner, TB; Haustermans, K; Huguet, F; Morganti, AG; Mukherjee, S; Belka, C; Krempien, R; ... Roeder, F; + view all (2020) ESTRO ACROP guidelines for target volume definition in pancreatic cancer. Radiotherapy and Oncology 10.1016/j.radonc.2020.07.052. (In press). Green open access

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Abstract

Despite of the predominant role of chemotherapy and surgery in pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) still has a place in multimodal management of this disease where local tumour sequelae are fatal in about 40% of the patients. RT (chemoradiotherapy and stereotactic body radiotherapy) is used and investigated in the non-metastatic setting as part of definitive treatment strategies, in (neo)adjuvant settings and for locally recurrent disease. The ACROP committee was delegated by ESTRO to recommend target volume delineation for these clinical situations. The guidelines of this document are a result of a structured evaluation of the best available evidence by a panel of international experts in the field. Guidance for treatment planning including diagnostic imaging is provided. Recommendations are given for GTV delineation. The role and the definition of CTV volumes are critically discussed. Aspects of motion management and patient positioning are taken into account for PTV definition. Furthermore, aspects of delineation of organs at risk and of dose constraints are described in both, standard and hypofractionated, settings. This guideline has the purpose to support standardised and optimised processes of RT treatment planning for both, clinical practice and prospective studies.

Type: Article
Title: ESTRO ACROP guidelines for target volume definition in pancreatic cancer
Location: Ireland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.radonc.2020.07.052
Publisher version: https://doi.org/10.1016/j.radonc.2020.07.052
Language: English
Additional information: This is an Open Access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Licence (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Pancreatic cancer, Radiotherapy, Target volumes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10109335
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