Aki, D;
Ulag, S;
Unal, S;
Sengor, M;
Ekren, N;
Lin, C-C;
Yılmazer, H;
... Gunduz, O; + view all
(2020)
3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering.
Materials & Design
10.1016/j.matdes.2020.109094.
(In press).
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Abstract
In this study, a novel Polyvinyl Alcohol (PVA)/Hexagonal Boron Nitride (hBN)/Bacterial Cellulose (BC) composite, bone tissue scaffolds were fabricated using 3D printing technology. The printed scaffolds were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), tensile testing, swelling behaviour, differential scanning calorimetry (DSC), and in vitro cell culture assay. Results demonstrated that bacterial cellulose addition affected the characteristic properties of the blends. Morphological studies revealed the homogenous dispersion of the bacterial cellulose within the 12 wt%PVA/0.25 wt%hBN matrix. Tensile strength of the scaffolds was decreased with the incorporation of BC and 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC had the highest elongation at break value (93%). A significant increase in human osteoblast cell viability on 3D scaffolds was observed for 12 wt%PVA/0.25 wt%hBN/0.5 wt%BC. Cell morphology on composite scaffolds showed that bacterial cellulose doped scaffolds appeared to adhere to the cells. The present work deduced that bacterial cellulose doped 3D printed scaffolds with well-defined porous structures have considerable potential as a suitable tissue scaffold for bone tissue engineering (BTE).
| Type: | Article |
|---|---|
| Title: | 3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.matdes.2020.109094 |
| Publisher version: | https://doi.org/10.1016/j.matdes.2020.109094 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Bacterial Cellulose; Bone Tissue Engineering; Hexagonal Boron Nitride; osteoblast cell line; Polyvinyl alcohol; 3D Bioprinting. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10108976 |
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